PNC-27 10mg

Description

PNC-27 10mg from Polaris Peptides is a lyophilised research peptide with over 99% purity confirmed by HPLC-MS. PNC-27 is a p53-HDM-2 binding peptide (also known as p53-derived membrane-active peptide), supplied vacuum-sealed and sold strictly for laboratory research.

At $150.00 this vial works out to $15.00 per milligram.

What Is PNC-27 10mg?

PNC-27 is a 32-amino-acid peptide that combines a segment of the p53 protein that binds HDM-2 with a membrane-penetrating sequence. It was designed to study what happens when that p53 sequence meets HDM-2 on the surface of cell membranes.

Published in-vitro work reported that PNC-27 binds HDM-2 found on the membranes of certain cancer cell lines and forms pores, while sparing normal cells in those same studies. It remains a niche preclinical research tool in oncology and membrane biology.

PNC-27 10mg Specifications

Product	PNC-27 10mg
Compound	PNC-27
Also known as	p53-derived membrane-active peptide
Class	P53-HDM-2 binding peptide
Amount	10mg
Form	Lyophilised powder
Purity	>99% (HPLC-MS)
Packaging	Vacuum-sealed
Storage	−20 °C dry; 2–8 °C once reconstituted
SKU	PLPNC10

PNC-27 Research Areas

Published studies on PNC-27 cover several areas. The list below summarises the main ones so you can see where it fits your work.

• p53-HDM-2 interaction: binding of the p53 sequence to HDM-2.
• Membrane biology: pore formation and membrane disruption.
• Oncology cell-line research: selective activity against certain tumour cell lines in vitro.
• Peptide design: fusion of a binding domain with a penetrating sequence.

Storing and Handling PNC-27 10mg

Store unopened vials at −20 °C, where the dry powder stays stable for long periods. Before reconstitution, let the vial reach room temperature to stop condensation forming inside. Add bacteriostatic water or another lab-grade solvent slowly down the side of the vial and swirl gently rather than shaking. Once reconstituted, keep it at 2–8 °C and complete your work within 28 days.

Why Order PNC-27 From Polaris Peptides

Every batch of PNC-27 we sell is checked by HPLC-MS for identity and purity before it is listed. Vials are vacuum-sealed to keep moisture out and labelled with the exact amount. If you are comparing suppliers, ask for the batch analysis and check it against the label. That is the standard we hold ourselves to.

How PNC-27 10mg Is Tested

We use two methods together. High-performance liquid chromatography (HPLC) separates the contents of a sample so we can see how much of it is the target compound and how much is anything else, such as truncated sequences or leftover synthesis reagents. Mass spectrometry (MS) then weighs the molecules, which confirms that the main peak really is PNC-27 and not a look-alike. A result above 99% on both counts is what earns a batch a place in our catalogue. Lots that fall short are not sold.

Related Research Peptides

Researchers working with PNC-27 10mg often look at FOXO4-Dri 10mg, LL-37 10mg, Thymosin Alpha-1 10mg, SS-31 25mg (elamipretide). Browse the full Immune & Cellular Peptides collection, or see every compound in the peptide shop.

PNC-27 10mg FAQ

What is PNC-27 made of?

A p53 segment that binds HDM-2, joined to a membrane-residency sequence that helps the peptide reach the cell membrane.

Is PNC-27 a treatment?

No. It is an early-stage research compound studied in cell lines. It is sold for laboratory research only.

What purity is PNC-27 10mg?

Over 99%, confirmed by HPLC-MS on every batch.

How should PNC-27 be stored?

Dry powder at −20 °C. After reconstitution, 2–8 °C, used within 28 days.

Is PNC-27 10mg for human use?

No. It is sold for laboratory and in-vitro research only. It is not a drug, food or cosmetic and is not for human or veterinary use.

References

Read the published research on PNC-27 at PubMed (U.S. National Library of Medicine).

For laboratory research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease. These statements have not been evaluated by the FDA.