Description
Retatrutide 10mg from Polaris Peptides is a lyophilised research peptide with over 99% purity confirmed by HPLC-MS. Retatrutide is a GIP / GLP-1 / glucagon triple receptor agonist (also known as LY3437943, triple G), supplied vacuum-sealed and sold strictly for laboratory research.
At $89.00 this vial works out to $8.90 per milligram. It sits in the middle of our range, a practical size for full study runs without committing to a bulk vial.
What Is Retatrutide 10mg?
Retatrutide is a single peptide engineered to activate three receptors: GIP, GLP-1 and glucagon. It carries a fatty diacid side chain for albumin binding, which supports a weekly profile in published studies. Researchers often call it a ‘triple agonist’ or ‘triple G’.
Adding glucagon receptor activity is the interesting part. Glucagon raises energy expenditure and influences liver fat metabolism, so retatrutide lets labs study whether pairing it with the two incretins changes outcomes compared with dual agonists like tirzepatide. Phase 2 data published in 2023 made it one of the most discussed compounds in the field.
Retatrutide 10mg Specifications
| Product | Retatrutide 10mg |
|---|---|
| Compound | Retatrutide |
| Also known as | LY3437943, triple G |
| Class | GIP / GLP-1 / glucagon triple receptor agonist |
| CAS number | 2381089-83-2 |
| Amount | 10mg |
| Form | Lyophilised powder |
| Purity | >99% (HPLC-MS) |
| Packaging | Vacuum-sealed |
| Storage | −20 °C dry; 2–8 °C once reconstituted |
| SKU | PLR10 |
Retatrutide Research Areas
Published studies on Retatrutide cover several areas. The list below summarises the main ones so you can see where it fits your work.
- Triple-receptor pharmacology: how GIP, GLP-1 and glucagon signals combine or offset each other.
- Energy expenditure: glucagon-driven thermogenesis and metabolic rate in animal models.
- Hepatic lipid metabolism: liver fat reduction, a major secondary endpoint in published retatrutide work.
- Weight-regulation benchmarks: comparisons against semaglutide and tirzepatide in obesity models.
- Glucose homeostasis: balancing glucagon’s glucose-raising effect against incretin-driven insulin release.
Storing and Handling Retatrutide 10mg
Store unopened vials at −20 °C, where the dry powder stays stable for long periods. Before reconstitution, let the vial reach room temperature to stop condensation forming inside. Add bacteriostatic water or another lab-grade solvent slowly down the side of the vial and swirl gently rather than shaking. Once reconstituted, keep it at 2–8 °C and complete your work within 28 days.
Why Order Retatrutide From Polaris Peptides
Every batch of Retatrutide we sell is checked by HPLC-MS for identity and purity before it is listed. Vials are vacuum-sealed to keep moisture out and labelled with the exact amount. If you are comparing suppliers, ask for the batch analysis and check it against the label. That is the standard we hold ourselves to.
How Retatrutide 10mg Is Tested
We use two methods together. High-performance liquid chromatography (HPLC) separates the contents of a sample so we can see how much of it is the target compound and how much is anything else, such as truncated sequences or leftover synthesis reagents. Mass spectrometry (MS) then weighs the molecules, which confirms that the main peak really is Retatrutide and not a look-alike. A result above 99% on both counts is what earns a batch a place in our catalogue. Lots that fall short are not sold.
Related Research Peptides
Retatrutide is also available in other sizes: Retatrutide 5mg, Retatrutide 15mg, Retatrutide 35mg, Retatrutide 60mg.
Researchers working with Retatrutide 10mg often look at Tirzepatide 5mg, Semaglutide 10mg, Survodutide 5mg, Mazdutide 6mg. Browse the full GLP-1 & GIP Analogues collection, or see every compound in the peptide shop.
Retatrutide 10mg FAQ
Why does retatrutide include glucagon activity?
Glucagon receptor activation is linked to higher energy expenditure and changes in liver fat handling. Retatrutide lets researchers study that effect alongside GIP and GLP-1 in one molecule.
Is retatrutide the same as tirzepatide?
No. Tirzepatide is a dual GIP/GLP-1 agonist. Retatrutide is a separate molecule that adds glucagon receptor agonism.
What purity is Retatrutide 10mg?
Over 99%, confirmed by HPLC-MS on every batch.
How should Retatrutide be stored?
Dry powder at −20 °C. After reconstitution, 2–8 °C, used within 28 days.
Is Retatrutide 10mg for human use?
No. It is sold for laboratory and in-vitro research only. It is not a drug, food or cosmetic and is not for human or veterinary use.
References
Read the published research on Retatrutide at PubMed (U.S. National Library of Medicine).
For laboratory research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease. These statements have not been evaluated by the FDA.
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