Description
Semaglutide 2mg from Polaris Peptides is a lyophilised research peptide with over 99% purity confirmed by HPLC-MS. Semaglutide is a GLP-1 receptor agonist (also known as GLP-1 analogue, NN9535), supplied vacuum-sealed and sold strictly for laboratory research.
At $30.00 this vial works out to $15.00 per milligram. It is the smallest size we stock, which makes it a good fit for pilot experiments, method development or a first look at the compound.
What Is Semaglutide 2mg?
Semaglutide is a 31-amino-acid analogue of human glucagon-like peptide-1 (GLP-1). Two changes set it apart from the native hormone: an Aib substitution at position 8 that blocks breakdown by the enzyme DPP-4, and a C-18 fatty diacid chain attached to lysine 26 that lets the molecule bind albumin in circulation. Together those edits stretch its half-life from minutes to roughly a week in published pharmacokinetic work.
That long, stable activity is the reason semaglutide has become the reference compound in incretin research. Labs use it as a benchmark when they study GLP-1 receptor signalling, compare newer dual and triple agonists, or model how appetite and glucose control are regulated by the gut-brain axis.
Semaglutide 2mg Specifications
| Product | Semaglutide 2mg |
|---|---|
| Compound | Semaglutide |
| Also known as | GLP-1 analogue, NN9535 |
| Class | GLP-1 receptor agonist |
| CAS number | 910463-68-2 |
| Amount | 2mg |
| Form | Lyophilised powder |
| Purity | >99% (HPLC-MS) |
| Packaging | Vacuum-sealed |
| Storage | −20 °C dry; 2–8 °C once reconstituted |
| SKU | PLS2 |
Semaglutide Research Areas
Published studies on Semaglutide cover several areas. The list below summarises the main ones so you can see where it fits your work.
- GLP-1 receptor signalling: how sustained receptor activation affects cAMP production, insulin secretion and beta-cell response in cell and animal models.
- Appetite and energy balance: the role of hypothalamic and brainstem GLP-1 receptors in food intake and gastric emptying.
- Metabolic disease models: glucose tolerance, insulin sensitivity and body-weight outcomes in diet-induced obesity studies.
- Cardiovascular and renal endpoints: secondary markers explored in large published trials, including blood pressure and lipid profiles.
- Comparator studies: a well-characterised baseline when testing tirzepatide, retatrutide, cagrilintide combinations and other next-generation analogues.
Storing and Handling Semaglutide 2mg
Store unopened vials at −20 °C, where the dry powder stays stable for long periods. Before reconstitution, let the vial reach room temperature to stop condensation forming inside. Add bacteriostatic water or another lab-grade solvent slowly down the side of the vial and swirl gently rather than shaking. Once reconstituted, keep it at 2–8 °C and complete your work within 28 days.
Why Order Semaglutide From Polaris Peptides
Every batch of Semaglutide we sell is checked by HPLC-MS for identity and purity before it is listed. Vials are vacuum-sealed to keep moisture out and labelled with the exact amount. If you are comparing suppliers, ask for the batch analysis and check it against the label. That is the standard we hold ourselves to.
How Semaglutide 2mg Is Tested
We use two methods together. High-performance liquid chromatography (HPLC) separates the contents of a sample so we can see how much of it is the target compound and how much is anything else, such as truncated sequences or leftover synthesis reagents. Mass spectrometry (MS) then weighs the molecules, which confirms that the main peak really is Semaglutide and not a look-alike. A result above 99% on both counts is what earns a batch a place in our catalogue. Lots that fall short are not sold.
Related Research Peptides
Semaglutide is also available in other sizes: Semaglutide 10mg, Semaglutide 5mg, Semaglutide 12.5mg, Semaglutide 20mg.
Researchers working with Semaglutide 2mg often look at Tirzepatide 5mg, Cagrilintide 3mg, Semaglutide 3mg Blend (SALE!), Retatrutide 5mg, Cagrilintide 5mg. Browse the full GLP-1 & GIP Analogues collection, or see every compound in the peptide shop.
Semaglutide 2mg FAQ
How is semaglutide different from native GLP-1?
Native GLP-1 is cleared within a few minutes. Semaglutide carries an amino-acid swap that resists DPP-4 and a fatty-acid side chain that binds albumin, so it stays active far longer in research models.
Which compounds is semaglutide usually compared against?
Tirzepatide (GIP/GLP-1), retatrutide (GIP/GLP-1/glucagon), mazdutide, survodutide and the amylin analogue cagrilintide are the most common comparators in current literature.
What purity is Semaglutide 2mg?
Over 99%, confirmed by HPLC-MS on every batch.
How should Semaglutide be stored?
Dry powder at −20 °C. After reconstitution, 2–8 °C, used within 28 days.
Is Semaglutide 2mg for human use?
No. It is sold for laboratory and in-vitro research only. It is not a drug, food or cosmetic and is not for human or veterinary use.
References
Read the published research on Semaglutide at PubMed (U.S. National Library of Medicine).
For laboratory research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease. These statements have not been evaluated by the FDA.
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